Graphical AbstractYeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.

Koonin argues that CRISPR-Cas systems present the best-known case in point for Lamarckian evolution because they satisfy his proposed criteria for the specific inheritance of acquired adaptive characteristics. We see two interrelated issues with Koonin’s characterization of CRISPR-Cas systems as Lamarckian. First, at times he appears to confuse an account of the CRISPR-Cas system with an account of the mechanism it employs. We argue there is no evidence for the CRISPR-Cas system being “Lamarckian” in any sense. Second, it is unclear (...) whether the mechanism is more “Lamarckian” than many other forms of genetic change already well-characterized in Darwinian terms. We present three conceptually distinct senses in which the mechanism of IAC may be considered Lamarckian and argue that only the strongest sense of goal-directed IAC would be difficult to accommodate in a Darwinian account. As the CRISPR-Cas mechanism does not qualify as “Lamarckian” in this strong sense, we argue there is no conceptual value in calling it “Lamarckian”. Finally, we suggest that CRISPR-Cas systems do hold the potential for genuinely non-Darwinian, directed evolution in a way that Koonin did not discuss, involving their potential use as a human gene-editing tool. (shrink)

Published in 2018, ‘Re:Print’ is an experimental artists’ book, edited by Véronique Chance and Duncan Ganley, that brings together images and text by 20 contributors whose work addresses the role and language of the reproducible image. This article by Duncan Ganley discusses the challenges of translating artworks and text originally presented in the context of an exhibition and symposium, into a work of print an artists’ book. The range of contributors emphasizes the diverse scope of forms, processes and (...) ideas in the expanded field of Printmaking. Addressing a variety of approaches to integrating and repurposing this visual and textual material for the printed page, the article outlines the theoretical underpinning of the creation of ‘Re:Print’ and the editorial and design decisions taken to create a hybridized form that is both document and artwork and aims to draw out new agencies of the ‘book’ in a digital world. (shrink)

Drawing on his investigation of over one hundred mid-Victorian British newspapers and periodicals, Alvar Ellegård describes and analyzes the impact of Darwin's theory of evolution during the first dozen years after the publication of the Origin of Species . Although Darwin's book caused an immediate stir in literary and scientific periodicals, the popular press largely ignored it. Only after the work's implications for theology and the nature of man became evident did general publications feel compelled to react; each social group (...) responded according to his own political and religious prejudices. Ellegård charts the impact of this revolution in science, maintaining that although the idea of evolution was generally accepted, Darwin's primary contribution, the theory of natural selection, was either ignored or rejected among the public. (shrink)

As research involving gene editing continues to advance, we are headed in the direction of being able to modify the human germline. Should we reach a point where an argument can be made that the benefits of preventing unborn children and future generations from inheriting genetic conditions that cause tremendous suffering outweigh the risks associated with altering the human germline, the next step will be to design clinical trials using this technology in humans. These clinical trials will likely require careful (...) follow-up and monitoring of future generations born with altered genes. This paper addresses some of the ethical issues raised by intergenerational monitoring and sets out to show that these issues can be avoided with careful consideration and clinical trial design. (shrink)

Drawing on work in psychophysics, psychometrics, and sensory neurophysiology, Clark analyzes the character and defends the integrity of psychophysical explanations of qualitative facts, arguing that the structure of such explanations is sound and potentially successful.

Many philosophers doubt that one can provide any successful explanation of sensory qualities - of how things look, feel, or seem to a perceiving subject. To provide such an explanation, one would need to explain qualitative facts in non-qualitative terms. Attempts to construct such explanations have seemed, in principle, doomed. Austen Clark examines the strategy used in psychophysics, psychometrics, and sensory neurophysiology to explain qualitative facts. He argues that this strategy could succeed: its structure is sound, and it can (...) answer the various philosophical objections lodged against it. On this basis Professor Clark presents an analysis of senosry qualities that offers the possibility of explaining at least some qualia, and he sketches how this scheme might eventually reduce to neurophysiology. If he is correct, we are not doomed to an eternity of mere acquaintance with our qualia. (shrink)

Consequentialist theories that directly assess multiple focal points face an important objection: that one right option may conflict with another. Robert Adams raises an instance of this objection regarding the possibility that the right act conflicts with the right motives. Whereas only partial responses have previously been given, assuming particular views of the relation between motives and acts, an exhaustive treatment is in order. Either motives psychologically determine acts, or they do not – and I defend direct consequentialism on each (...) assumption. Crucially, if motives determine acts, this may be compatible with the ability to act otherwise, but there remains a defense for consequentialism even on these assumptions. What clears consequentialism of conflict is not necessarily that the apparently right act is unavailable, but rather that its outcome is suboptimal once we account for necessary motives. Even if the agent remains free to perform the act, the act costs too much. (shrink)

This is part of a complete set of Jane Austen's novels collating the editions published during the author's lifetime and previously unpublished manuscripts. The books are illustrated with 19th century plates and incorporate revisions by experts in the light of subsequent research.

Drawing on the findings of neuroscience, this text proposes and defends the hypothesis that the various modalities of sensation share a generic form that the author, Austen Clark, calls feature-placing.

"First edition 1954. Reprinted 1958, with revisions 1963, 1965, with further revisions by B.C. Southam 1969...".

This paper contrasts three different schemes of reference relevant to understanding systems of perceptual representation: a location-based system dubbed "feature-placing", a system of "visual indices" referring to things called "proto-objects", and the full sortal-based individuation allowed by a natural language. The first three sections summarize some of the key arguments (in Clark, 2000) to the effect that the early, parallel, and pre-attentive registration of sensory features itself constitutes a simple system of nonconceptual mental representation. In particular, feature integration--perceiving something as (...) being both F and G, where F and G are sensible properties registered in distinct parallel streams--requires a referential apparatus. Section V. reviews some grounds for thinking that at these earliest levels this apparatus is location-based: that it has a direct and nonconceptual means of picking out places. Feature-placing is contrasted with a somewhat more sophisticated system that can identify and track four or five "perceptual objects" or "proto-objects", independently of their location, for as long as they remain perceptible. Such a system is found in Zenon Pylyshyn's fascinating work on "visual indices", in Dana Ballard's notion of deictic codes, and in Kahneman, Treisman, and Wolfe's accounts of systems of evanescent representations they call "object files". Perceptual representation is a layered affair, and I argue that it probably includes both feature-placing and proto-objects. Finally, both nonconceptual systems are contrasted with the full-blooded individuation allowed in a natural language. (shrink)

University of Connecticut Storrs, CT 06279-2054. Recent versions of objectivism can reply to the argument from metamers. The deeper rift between subjectivists and objectivists lies in the question of how to explain the structure of qualitative similarities among the colors. Subjectivism grounded in this fashion can answer the circularity objection raised by Dedrick. It endorses skepticism about the claim that there is some one property of objects that it is the function of color vision to detect. Color vision may enable (...) us to detect differences in spectral composition without granting us the capacity to detect identities. (shrink)

Suppose we admit for the sake of argument that "folk" explanations of human behavior--explanations in terms of beliefs and desires--sometimes succeed. They sometimes enable us to understand and predict patterns of motion that otherwise would remain unintelligible and unanticipated. Is the only explanation for such success that folk psychology is a viable proto-scientific theory of human psychology? I shall describe an analysis which yields a negative answer to that question. It was suggested by an observation and an analogy, both of (...) which may initially seem remote from the topic at hand. (shrink)

When you suffer a pain are you suffering a sensation? An emotion? An aversion? Pain typically has all three components, and others too. There is indeed a distinct sensory system devoted to pain, with its own nociceptors and pathways. As a species of somesthesis, pain has a distinctive sensory organization and its own special sensory qualities. I think it is fair to call it a distinct sensory modality, devoted to nociceptive somesthetic discrimination. But the typical pain kicks off other processes (...) too. For one it can grab your attention in a distinctive way, alerting you to its presence and sometimes obliging you to focus attention on the damaged member. Intense pain can eliminate your ability to think about anything else. Pain typically has direct and immediate motivational consequences: one wants it to stop, has an incentive to do whatever one can to reduce it, and is gratified by its termination. As these desires and motives collide with neural reality, emotional components of mental anguish, anxiety, and dread arise. The suffering involved in suffering from pain has multiple strands: it is not just the painfulness of the sensation, or the frustration of the desire that it end, but also the anguish over the possibility that it will never end, and the impossibility, if the pain is sufficiently intense, of focusing one’s attention on anything else. (shrink)

The goal of this paper is to challenge the rather insouciant attitude that many investigators seem to adopt when they go about describing the items and events in their " visual fields". There are at least three distinct categories of interpretation of what these reports might mean, and only under one of those categories do those reports have anything resembling an observational character. The others demand substantive revisions in one's beliefs about what one sees. The ur-concept of a " visual (...) field" is that of the "sum of things seen", but one can interpret the latter in very different ways. The first is the "field of view", or the sum of physical things seen. The second is an array of visual impressions, whose spatial relations are distinct from those of physical phenomena in front of the eyes. The third is an intentional object: the world as it is represented visually. These three categories are described, and various locutions of vision science--such as "optic array", "retinocentric space", " visual geometry", "virtual object" and others--are analyzed and variously located within them. Finally, a recent argument purporting to necessitate the existence of a version two visual field is examined and shown wanting. (shrink)

If one examines the sky at sunset on a clear night, one seems to see a continuum of colors from reds, oranges and yellows to a deep blue-black. Between any two colored points in the sky there seem to be other colored points. Furthermore, the changes in color across the sky appear to be continuous. Although the colors at the zenith and the horizon are obviously distinct, nowhere in the sky can one see any color borders, and every sufficiently small (...) region of the sky is made up of regions that all seem to be of the same color. (shrink)

A neighbor who strikes it rich evokes both admiration and envy, and a similar mix of emotions must be aroused in many neighborhoods of cognitive science when the residents look at the results of research in color perception. It provides what is probably the most widely acknowledged success story of any domain of scientific psychology: the success, against all expectation, of the opponent process theory of color perception. Initially proposed by a Ewald Hering, a nineteenth century physiologist, it drew its (...) inspiration from the existence of opposing muscle groups. Hering thought that analogous opposing processes could explain some aspects of color perception, but the resulting theory was more complicated and less intuitive than that proposed by the great Hermann von Helmholtz. Helmholtz carried his day, but in the long run Hering turned out to be right. (shrink)